Captive cell therapy test based on Bob Langer research is still terminated, the latest results will be issued next month

In July this year, Flagship Pioneering (FP) hatched package cell therapy Xinrui Sigilon Therapeutics Inc. (NASDAQ: SGTX) received the US FDA notification, suspended its patients with moderate or severe hemophilia for moderate or severe hemophilia Clinical trials of I / II.

The discontinuation of this test was due to a "a common treatment complication" in a patient. Prior to this, SIGILON has submitted a serious adverse event (SAE) report to the FDA and other regulators and suspend registration processes.

SIGILON launched in 2017 Robert Langer and Daniel Anderson laboratory in MIT. It is reported that SIGILON is listed in Nasdaque in December last year, and the market value is once more than 1 billion US dollars. At present, the company’s market value is only $ 122 million. And after the price of $ 18 in 18 US dollars, SIGILON is only slightly above $ 3.5 after the price of $ 48.

Robert Langer and MIT Daniel Anderson Laboratory research results based on Moderna Important Behind: SIGILON established the SIGILDED LIVING Therapeutics? (SLTX) technology platform, the engineering cell package is implanted into the patient. Its technical purpose is to protect the influence of the cells from the human immune system and prevent side effects. Therefore, some investors expressed concern for the test caused by complications due to complications.

Recently, SIGILON announced that after a patient in clinical study of only three people reported a serious adverse incident, the patient received laparoscopic surgery specified by the researcher to remove the implanted sphere. After inspection, it was determined that the sphere placed in the patient was already fibrilized, and the cells in the sphere no longer have vitality.

The patient accepted the highest dose in three individuals receiving the treatment, and there was a factor VIII antibody after the spherical implantation, which may be the cause of the patient to face uncontrolled bleeding risks.

Although the company surveyed the patient’s fibrotic sphere, all three patients participating in the SIG-001 test will continue to follow up in accordance with the research agreement. These findings may have an impact on the time of Patients in the I / II clinical trial of the SIG-005 I-type Polycharant Storage (MPS-1).

"Guaranteed patient safety is our primary task, we are collecting information to understand these observations," said Dr. Rogerio Vivaldi, President and CEO of Sigilon, "We will work closely with FDA, other regulators and company consultants to determine these Observation results on our project. "

Figure | Color scanning electron micrograph of blood clots (Source: The New York Times)

Hemophilia is a hereditary disease due to the lack of certain coagulation factors in the blood. The main manifestation of this disease is that it is difficult for blood and blood, and traditional therapy is long-term infusion condensation factor VIII.

Sigilon developed SIG-001 Hemophilia Type Tytopathic, by encapsulating cells that produce coagulation factor VIII into a semi-permeable protective film and implanted into a patient, while producing Caggered Factor VIII (FVIII) Free from an immune system attack and prevent scar tissue around it.

The SIGILON product line is mainly for three types of disease treatment: rare blood disease, lysosome disease and endocrine and other chronic diseases. It is to be explained that SIG-001 is the only major candidate drug that the company enters the clinical stage. If the test cannot be recovered, then SIGILON’s main push line will become two lysosomes that are currently undergoing clinical test. therapy.

Figure SIGILON R & D line (Source: SIGILON)

It is still unclear whether treatment has led to this adverse reaction incident, and the company spokesperson Brandon Hagen refused to express comments after the press release. SIGILON said in its published message, the results will be reviewed and evaluated in the SIG-001 Security Review Committee on next month.



Bihui "The Innovative Application of Life Science Qihai Tracking Biotechnology" series audio program officially launched, we will take you to explore more interesting life science industry!

Unique robot CEO Wang Guangneng: Robot and artificial intelligence combine, is the development direction of the robot | 2021 WISE Yuan Universe · Robot Summit

Since 2021, the robotic track has been popular with capital. There are 299 robot projects that have been financing in the first 10 months, of which 253 are concentrated in c rounds, and the financing of 79 projects is above billion yuan.

The sky-eye check data also shows that this new robot related enterprise has exceeded 100,000. Up to now, there are more than 320,000 robots related companies (enterprise names or business ranges). In the region, there are more than 70,000 related companies in Guangdong Province, accounting for 22.02%. It is the second in Jiangsu nearly 2 times.

Therefore, in this industry and capital double background, 36 was held in Shenzhen on November 25 in Shenzhen. The summit invited many investors, scientists, scholars, outstanding entrepreneurs and related practitioners to discuss new trends in the industry, and how to make technology into the public in the new environment. The guests include the Chinese Academy of Engineering Tan Jianrong, Dashamith, Ministry, Guan Chi, General Manager, General Manager of Lan Chi, Alibaba Bada Human Voice Laboratory Researcher, Gaoxian Robot founder and CEO Cheng Haotian, big robot CEO Wang Guangneng, the founder of the future robot, Li Luyang, the executive president of Yunhara Technology and CTO Lin Xiaojun and other guests.

At the summit, the generic CEO King Guangneng believes that combined with artificial intelligence technology, you can make the robot to understand the environment and interact with the environment, and make everyone useful to use it very easily. It is an important direction for the development of the robot.

The following is the "Edited) of Wang Guangneng Speech (edited):

What is the big robot? Summarize a sentence,Use robot technology to serve. At present, the big economy willNearly 400 people, more than half of them are engineers, and members come from more than 20 countries.. We have set up a double headquarters in China and Germany, mainly producing in Shenzhen.But later in Foshan, establish a production base for 15,000 units.

Now, the market has appeared in many kinds of robots, more typical as URs, there are several domestic, while the big robots have certain differentiation. For example, six-axis collaboration robot, in terms of various performance, such asIntelligence,Precision,Safety protection levelWait, excellent performance, these indicators are at a high level in the industry.

But in the past two years, there have been many companies in collaborative robots, and there are almost over 130 in the world. Observing these robots will find a common feature: relative to traditional industrial robots, they just step forward, this short step is to make robots better and safer. But in fact, this is not the ultimate morphology of the robot, and the robot should develop in the intelligent direction. So we believe that combined with artificial intelligence technology, we can let the robots perceive the environment and interact with the environment, and can make everyone use it very easily. This is an important direction for the development of the robot industry.

So our philosophy is that the robot can sense the environment and interact with the environment. The most important thing is that it can make more people to use, operate, such as the clerk of the company’s front desk, and the production workers can operate, and it is best to be able to industrial production lines. Let it work. Instead, like traditional industrial robots, engineers who need trained can be used by programming.

So we develop third-generation collaborative robot – Maira,It is a robot combined with artificial intelligence. In March this year, we have released many international awards, such as the Red Point Award, 2021 European Product Design Award, German Innovation Award. As our third-generation robot, Maira has a very high hard indicator, because as a seven-axis robot arm, its own indicator foundation is very good, including load capacity, arm exhibition, and some improvement robots on the market. . In terms of freedom,The third generation robot is upgraded to seven degrees of freedom.

At the same time, we have developed some of the internal core components, including motors, encoders, can be achieved with 1.4 m arm exhibitions in collaboration robots, and the repeated positioning accuracy reaches 6 to 10 microns, which is the highest level in the industry. It takes a lot of efforts to achieve this level, including sensors, structures, real-time control, and model-based control.

In addition, the speed of MAIRA can reach 4.5 meters per second. We also have a lot of interfaces, and even 3 airways are in it. A 6-dimensional force sensor is added, and the accuracy of force can reach 0.1 Newton.

The collaborative robot is to be safe, so it will not be high. So how do we solve safety? Most of the collaborative robots on the market are now stopped from being stopped, and avoid harm to operators. So we joined the sensor to let the robots understand the environment.Perceived the action of people within 3 meters around.Just like an automatic driving car, you can perceive the surrounding situation in advance.So this is a more advanced security measures that can surpass the current collaboration robot.

In terms of operation, people don’t need to touch directly. When no one is no, it can move normally. When someone can feel people, it doesn’t need you to stop in the future. Even you suddenly intervene, it can also feel and avoid actions.

What’s more interesting is that a very important factor that makes the machine’s smart is visual. After the robot visual, it can do a lot, a basic function is that it can scan the surrounding environment, including the operator, table, table, objects that can be captured, etc., can be scanned. And in its system, the three-dimensional model is built and do it in the virtual environment.

After the robot comes with 3D visual, there is no need to add additional visual, and its own visual is enough to understand the environment and can operate. Like this video, various forms, various hardness objects, it can be captured. And things that are randomly thrown, it can also be identified, which is the benefits of visual and artificial intelligence.

In industrial, welding, grinding, dispensing, etc., requires a very complex robot programming, after robotic visual and artificial intelligence, allowing the entire program to make it very simple. Our philosophy is to let people and robots communicate directly.

Let’s make the mechanical arm that can do industrial.And let speech control it, ie voice recognition. In the first half of our Demo, it is basically a semantic understanding. We also integrate six-dimensional tactile sensors that allow the robot to operate very accurately.

In fact, after collaboration robots are used with artificial intelligence, they can apply in very many fields. Like traditional industrial automation workshops, logistics industry, automotive production workshops, medical automation laboratories, machine tool processing workshops, and even in the field of medical, surgery, and rehabilitation.

And intelligence, it can avoid complex programming. We believe that the future robots can develop like a smart, even the body is likely to be closer.

Open source big face: InsightFace takes you to create a face recognition system for unpacking


Referring to the open source technology of artificial intelligence and face recognition, I believe that many peers in the industry should be unfamiliar with InsightFace, which is quoted more than 2100+, since 2018 Open Source, also maintains a strong growth situation in GitHub .

It can also be seen on the actual effect map displayed in the project.

And in the past year, InsightFace continues to maintain strong and active updates:

Among them, there is a large number of new progress in academic circles, international competitions (ICCV21, NIST-FRVT), and also supports a variety of frameworks (MXNET, Pytorch, PaddlePaddle).

1 InsightFace Framework

Insightface is an open source 2D & 3D deep face analysis toolbox, which highly enables rich and diverse face recognition, face detection and face algorithm, and optimized for training and deployment, assessing, competition in multiple algorithms. Get a winning.

2 Added support based on PaddlePaddle framework implementing a face recognition system

Based on the arser-based Blazeface, ArcFace and MobileFace, unpacking and a certain speed advantage, support large-scale distributed training, high throughput, and support 60 million categories.

(1) ARCFACE model is open and has a certain speed advantage

  • Use the box

  • Speed ??advantage

(2) The RESNET large-scale distributed training rate is high, up to 60 million categories

  • Throughout the lead

  • Maximum support for 60 million categories

(3) a line of code practice simple face recognition Demo

Example scripts for detecting + identifying series predictions are as follows:

Python3.7 Tools / – Det – Rec –index=index.bin –input=Friends2.jpg –output=""

The final visual results are stored in the Output directory, and the visual results are shown below.


3 Welfare time

In order to make everyone more familiar with Insightface, understand the latest update progress, the InsightFac initiates people with the average developers, live in the B station, and share the latest progress for everyone.

4 Registration course joining technology exchange group


Annual intelligent luxury sedan

Award-winning enterprise: Zhishao Automobile Winners: L7

Comments: ZHECIAL L7 is a digital transformation of automotive enterprises, a brand new smart electric "beauty", excellent design, powerful performance, is integrated into this sedan species.

As a new user-type automotive technology company jointly created by the SAIC Group, Zhangjiang Gaoke and Alibaba Group, it has a relatively high starting point, which also carries the high-prime preferences of the outside world.

As the first flagship model of the brand, L7 first with "Yan", the automotive industry has developed more than a hundred years later, excellent native design can not meet, although the delivery is not delivered, but the design of Xihe L7 has been widely recognized. .

Zhixiang Automobile is inspired by "Horship, Water", and has extended the core design concept of "flowing" "natural" "to" integration "as keywords. On the eve of the Guangzhou Auto Show, the world’s first smart unbounded IMOS operating system is also officially released, new cars can Realize cross-screen display, multi-screen interaction, let interaction more free, the central screen and smart scene screen are perfectly integrated, so that the central screen is more convenient, and the smart scene screen shows more immersive. Thanks to this, every function in the L7 car is inseparable from the organic overall.

A intuitive example is the unique super-run mode of Xishao L7: After a button switching, the smart scene screen automatically switches to the half-screen immersion driving state, the speed is light efficient to the screen, the theater class smart acoustic system simulation V8 super run sound wave Matching 3.87 seconds of "V8" 百 动 百, sound and optical linkage creates a driving atmosphere of the super sports car, and the whole car CDC, vehicle acceleration brake response, atmosphere lamp and other modules cooperate.

Under the high look, don’t forget that L7 is a "hard" wisdom car. The intelligent car IM AD smart driving system has 32 high-performance perceived hardware, achieving 360 degree full coverage, multiple detection, mutual verification. Perceived ability; system uses artificial intelligent super algorithm, uses a perception-fusion-predictive-controlling full-process data-driven technical concept, based on massive data, through AI technology, allowing IM AD to learn, self-evolution. Previously, the IM AD smart driving system has been publicly measured on the road in the second line of urban districts, and the final mass production version, or more surprises.

In terms of performance, Zhishao L7 has a world-leading 0.21 ultra-low wind resistant coefficient, effective boosting mileage reaches 708 kilometers; front and rear motor and high performance four-wheel drive, comprehensive output can reach 578 horsepower / 725 cattle · rice, bring 3.87 seconds Bus accelerated.

Shareholders with strong strength, young and tuned, will be an important force in the future high-end pure electric vehicle. Southern reporter Zhong key is quite

On Artificial Intelligence: A new round of industrial revolution in artificial intelligence AI

Artificial intelligence is the current cutting-edge technology of technology, which will bring a new round of industrial revolution. Every big scientific and technological progress will change people’s lifestyle and habits, and artificial intelligence is no exception.

Today, social technology is rapidly developed, and the technology innovation has a new month. The sum of the human invention created by the human invention creation ratio of human invention in modern times. Scientific and technological progress brings people a longer life, richer food, larger living space. From the ocean to the land to the sky, even outer space, every place has technology power. We must respect science, but we also think about science.

Artificial intelligence also known as machine intelligence, it is a comprehensive discipline that has developed by computer science, control, informationism, neurophysiology, psychology, linguistics and other disciplines. From the perspective of the computer application system, artificial intelligence is how to create a man-made intelligent machine or intelligent system to simulate the ability of human intelligence activities to extend people’s intelligence.

Since the 1990s, with the development of hardware and software, the computer’s computing capacity has grown in an exponential level, while network technology is booming, ensuring that computers have sufficient conditions to run some requirement to be higher artificial intelligence software, and now Artificial intelligence has the basis for more realistic applications. At present, all countries in the world are investing a large number of human resources resources to study artificial intelligence.

The development direction of artificial intelligence and the impact on human beings

The development of technology is always more than people’s imagination. From some science fiction movies, some prospective research, we can know that future artificial intelligence may develop: fuzzy treatment, parallelization, neural network, and machine emotions. At present, artificial intelligence is a breakthrough, learning and associative function is being studied. The next step is to imitate the fuzzy treatment function of human right brains and the parallelization of the entire brain. Artificial neural network is a new field of future artificial intelligence applications, and future intelligent computers may be a combination of artificial neural networks that act as a host. Studies have shown that emotions are part of intelligence, rather than intelligent phase separation, so the next breakthrough in artificial intelligence may be to give computer emotional capabilities. Emotional Ability is critical to the natural exchange of computers and people.

Artificial intelligence has been in front of computer technology, the theory and discovery of artificial intelligence research to a large extent, will determine the development direction of computer technology. Today, there have been many outcomes of artificial intelligence research to enter people’s daily lives. In the future, the development of artificial intelligence technology will bring greater impact on people’s lives, work and education.

MediaTek chips vulnerability that could let apps spy on users now fixed

A MediaTek vulnerability allowed apps on phones with certain MediaTek chips to listen in users without them knowing. The vulnerability could have been a serious blow to user privacy on phones running MediaTek chipsets, but thankfully the issue was fixed back in October. A report by Check Point Research via Android Police detailed the vulnerability, that is related to AI and audio-processing. It could allow apps with the right code to get access to system-level audio information that apps usually do not have access to.

This would have allowed more advanced, malicious apps to launch an eavesdropping attack, where the app could listen in on sounds around the phone and send back information to an attacker remotely.

The report, however, explains that the vulnerability is complicated and the flaw is not easy to crack. The team at Check Point Research was able to document how the attack was achieved on a Xiaomi Redmi Note 9 5G via a complicated process that included exploiting a series of four vulnerabilities in MediaTek firmware.

A malicious app like the one we mentioned above, would not have been able to execute such an attack without prior knowledge of the vulnerability. However, that will no longer be possible since the flaw has been fixed.

The report doesn’t mention which devices or chipsets in particular were affected by the vulnerability. This is something MediaTek has not revealed either as of writing this story.

However, the report does mention the processors based on the so-called Tensilica APU platform, which is reportedly also found on some HiSilicon Kirin chipsets. Whether these chipsets were also affected by a similar vulnerability is unknown.